Composition comprising the naphtoquinone -based component as an active ingredient, to prevent or improve fatigue, cachexia, pain, cognitive decline and reduction of haematopoietic stem cells which are related side effects of drugs for anticancer treatment

摘要

The present invention refers to a composition comprising a naphthinone -based compound as an active ingredient,To prevent or improve fatigue,Cachexia,Pain,Cognitive decline and haematopoietic stem cell reduction,That are side effects related to the anticancer treatment of the drug. Specifically,It has been confirmed that the compounds based on naphthinone,Dunnione and beta -lapachone,Reduce secretion and production of inflammatory cytokines that are increased by anticancer treatment,And prevent fatigue,The cachexia,Cognitive decline and reduction of haematopoietic stem cells,That are side effects associated with anticancer treatment,And,Therefore,The compounds of dunnione and beta -lapachone,Pharmaceutically acceptable salts,Pro -drugs,Solvates or isomers thereof may effectively be used as a pharmaceutical composition to prevent or improve any or more side effects related to the selected anticancer drug treatment from the group consisting of fatigue,Cachexia,Pain,Cognitive decline,And reduction of haematopoietic stem cells.