COMBINATION OF ANTI-CD20 ANTIBODY, SELECTIVE P13 KINASE-DELTA INHIBITOR, AND BTK INHIBITOR FOR TREATING PROLIFERATIVE B CELL DISORDERS

摘要

Methods are provided for inhibiting proliferation of a b cell population comprising administering a combination of agents, comprising: (i) at least one selective p13k-delta inhibitor; (ii) at least one anti-cd20 antibody; and (iii) at least one bruton tyrosine kinase inhibitor (btk).Methods for treating proliferative B-cell disorders, such as hematological B-cell malignancies, as well as kits for carrying out the claimed methods are also provided.