METHOD FOR DETECTION OF ISCHEMICAL RENAL TUBULAR CELL INJURY AND METHOD TO IDENTIFY EXTENSION OF THIS INJURY

摘要

"Method and kit for detecting early onset of renal tubular cell injury". The present invention relates to a method and kit for detecting early onset of renal tubular cell injury using ngal as an early urinary biomarker. ngal is a small secreted polypeptide that is protease resistant and consequently readily detected in the urine following renal tubule cell damage. ngal protein expression is detected predominantly in proximal tubule cells in a dotted cytoplasmic distribution reminiscent of a secreted protein. The appearance of ngal in the urine is related to the dose and duration of renal ischemia and nephrotoxemia, and is a diagnosis of renal tubule cell damage and renal failure. ngal detection is also a useful marker for monitoring nephrotoxic side effects of drugs or other therapeutic agents.