Use of 5-hydroxy-2-hydroxymethyl-y-pyrone as macrophage activating agent in the fight against cutaneous leishmaniasis

摘要

use of s-hydroxy-2-hydroxymethyl-sym -pyrone as macrophage activating agent in the fight against cutaneous leisanuniosis. The present invention relates to the use of hmp (a secondary metabolite produced by filamentous fungus) as a stimulating agent of macrophage microbicidal activity to combat cutaneous leisununiosis (lc) caused by the protozoan leishmania (leishmania) amazonensis. The main mechanism of action was the activation of the microbicidal activity of these host cells by increasing the production of oxygen radicals, increasing the amount of lysosomes, increasing the actin filaments and microtubules, and increasing the characteristic spread of the activation state of these cells. , eliminating the infection agent. In this sense, the search for molecules that are easy to obtain and that do not depend on seasonality, besides presenting an efficient combat mechanism that does not cause adverse reactions is presented by hmp, a potential candidate for use in fighting lc at a minimum concentration of 50 109 µg / ml. Therefore, the result showed high leishmanicidal activity, which qualifies the use of hmp as a potent candidate to combat cutaneous leshmaniasis.