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bicyclic kinase inhibitor compound, its use, pharmaceutical composition and method for inhibiting pim kinase activity in a cell
bicyclic kinase inhibitor compound, its use, pharmaceutical composition and method for inhibiting pim kinase activity in a cell
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机译:双环激酶抑制剂化合物,其用途,药物组合物和抑制细胞中pim激酶活性的方法
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摘要
New compounds, compositions and methods of inhibition of Provirus Integration of Maloney Kinase (PIM kinase) activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one PIM kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase-mediated disorder, such as cancer.
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