Nucleic Acid molecules for the reduction of papd5 mRNA or papd7 to treat hepatitis B infection

摘要

The present Invention relates to a method for identifying a compound that prevents, Soothes and / or Inhibits infection by hepatitis B virus (HBV),Where a compound that reduces the expression and activity of Associated Domain containing protein 5 (PAP papd5) and / or PAP Associated Domain containing 7 (papd7) is identified as a CompoundTo Prevent, relieve and / or Inhibits HBV infection.The Invention also provides papd5 or papd7 Inhibitors for use in treatment and Prevention of HBV infection, as well as a combined Preparation comprising an inhibitor of PApd5 and an inhibitor of papd7 for simultaneous or Sequential use in the Treatment or prevention of HBV infection.The present Invention also encompasses a Pharmaceutical composition for use in the treatment and / or the Prevention of HBV Infection and a method for Monitoring the therapeutic Success duringThe Treatment of HBV infection.