CRITICAL FORMS ANNEXED TO ANNEXES A

摘要

This invention provides crystalline forms of (S,E)-4 -(2 -(3 -(3 -chloro -2 -fluoro -6 -(1H -tetrazol -1 -yl)phenyl)acryloyl)-5 -(4 -methyl -2 -oxopyrazine -1 -yl)-1,2,3,4 -tetrahydroisoquinoline 1 -carboxamido)benzoic acid and its solvents; methylMethods of preparation of such crystalline forms; pharmaceutical compositions including such crystalline forms; and methods of treatment of thromboembolic embolism or such crystalline forms or pharmaceutical compositions.