UNIONS AND METHODS FOR THE DISPOSAL OF MEDICINAL PRODUCTS NECESSARY TO THE MARKETING AUTHORISATION OF MEDICINAL PRODUCTS OR WASTE MATERIALS PROVISIONS OF THE FRENCH SELF

摘要

This disclosure is focused on compounds and methods for the treatment of fluid retention or salt overload -related disorders,such as heart failure (in particular,congestive heart failure),chronic kidney disease,end stage renal disease,Hepatic disease and fluid retention induced by a c -agonist activated hyperacidosis multiplier (PPAR) receptor. This revelation is directed at:in compounds and methods for the treatment of hypertension. This disclosure is also focused on compounds and methods for the treatment of gastrointestinal disorders.including treatment or reduction of pain associated with gastrointestinal disorders. Methods generally include administrationor in a mammal in need of a pharmacologically effective amount of a compound or a pharmaceutical formulation containing such a compoundDesigned to be essentially gastrointestinal (GI) active to inhibit neo -mediated sodium ions and virus antibody of hydrogen in it. Specifically,the method includes the administration to a mammal in need of a pharmacologically effective amount of a compound or a pharmaceutical formulation that: includes such a union,which inhibits the transfer of sodium and /or hydrogen ions into the GI gastrointestinal tract by NEE -3, -2 and / or -8 -mediated transfer of sodium and /or hydrogen ions and is designed to be a substance seemingly impermeable to the epithelial cell layer,or more specifically than the epithelium of the GI gastrointestinal tract. As a result of the substance which is essentially impenetrable,is not absorbed and is therefore essentially systematically unavailable,so as to limit the exposure of other internal bodies (e.g. of the liver,of the heart,the brain etc.) on it. This revelation is still focused on one method,where such a compound is administered to a mammal with a liquid absorption polymer,so that the combination acts as described above and additionally provides the ability to isolate the liquid and /or salt present in the stomach GI tube.