1 - ((3 - ((1-Piperazinyl) carbonyl) phenyl) methyl) -2,4 (1H, 3H) -quinazoline dione derivatives as PARP inhibitors for the treatment of cancer

摘要

Disclosed are 1-(arylmethyl)quinazoline-2,4(1H,3H)-diones thereof, represented by the Formula (I) wherein Ar, R1-R6 are defined herein. Compounds having Formula (I) are PARP inhibitors. Therefore, compounds of the invention may be used to treat clinical conditions that are responsive to the inhibition of PARP activity.