首页>
外国专利>
Use of Jagged 1 / Frizzled 4 as Cell Surface Marker for Isolation of Human Cardiac Ventricular Progenitor Cells
Use of Jagged 1 / Frizzled 4 as Cell Surface Marker for Isolation of Human Cardiac Ventricular Progenitor Cells
展开▼
机译:锯齿状1 /卷曲4作为分离人心脏心室祖细胞的细胞表面标记物的用途
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention provides Jagged 1 and Frizzled 4 as cell surface markers for isolating human cardiomyogenic ventricular progenitor cells, in particular progenitor cells that preferentially differentiate into cardiac ventricular muscle cells. Thus, the invention provides human ventricular progenitor (HVP) cells. The invention providesmethods of the separation of Islet 1+ Jagged 1+ ventricular progenitor cells and/or Islet 1+/Frizzled 4+ ventricular progenitor cells and/or Islet 1+/Jagged 1+/Frizzled 4+ ventricular progenitor cells, and the large scale expansion and propagation thereof. Large clonal populations of isolated Jagged 1+ and/or Frizzled 4+ ventricular progenitor cells are also provided. Methods ofuse of Jagged 1+ and/or Frizzled 4+ ventricular progenitor cells for cardiac repair or to improve cardiac function are also provided. Methods of using the Jagged 1+ and/or Frizzled 4+ ventricular progenitor cells for cardiac toxicity screening of test compounds are also provided.
展开▼