AlostÉricos positive modulators of acetylcholine receptor muscarÍnico M4

摘要

This paper reported pirimido Tricyclic Compounds, including compounds [4 ', 5' - 4.5] thieno [2,3-c] pyridazin-3 8 Amine, pirido [3 ', 2': 4.5] thieno [3,2-d] pyrimidine 4 Amine, pirazino [2 ', 3': 4,5] thieno [3,2-d] pyrimidine 4 Amine, pirido [3 ', 2': 4.5] furo [3,2-d] pyrimidine pirimido Amine and 4 - [4 ', 5' - 4.5] furo [2,3-c] pyridazin-3 8 - amineThat may be useful as positive allosteric modulators of the M4 muscarinic acetylcholine receptor (mAChR M4).In this paper also applies Methods of preparing the compoundsPharmaceutical compositions comprising the compounds and Methods of treatment of Neurological and Psychiatric Disorders associated with malfunction of acetilcol Muscarinic receptorIna using the compounds and compositions.