METHOD OF OBTAINING AMORPHOUS APREMILAST

摘要

The present invention relates to an amorphous apremilast of the formula I, (S) -2- [1- (3-ethoxy-4-methoxyphenyl) -2-methylsulfonylethyl] -4-acetylaminoisoindoline-1,3-dione, in particular, to methods for producing amorphous apremilast from the solvate of apremilast with tetrahydrofuran, their characteristics and use in the pharmaceutical composition.