STANDARD DOSES FOR IMMEDIATE RELEASE OF GHB OR ONE OF ITS THERAPEUTICALLY ACCEPTABLE SALTS, ADAPTABLE BY THE ORAL ROLL, AND THEIR APPLICATION TO MAINTAIN ALCOHOL REFUSAL

摘要

The present invention relates to immediate release, standard doses of GHB or one of its therapeutically acceptable salts, administered by oral route. Such standard doses contain from 0.37 to 1.75 g of GHB, more often in the form of sodium oxybate; when doses in the form of granules, such granules have the following composition (wt.% relative to the total mass of the granules): active ingredient (sodium oxybate): 50-60%; effervescent agent: 5-15%; thinner: 2-18%; binder: 3-10%; substrate (solid core granules): 15-25%; coating agent / flavoring / sweetening agent / lubricant: 3-6%. They are used to support the rejection of alcohol in patients with low or moderate alcohol dependence or with severe or very severe alcohol dependence, suffering from or not suffering from liver disease.