COMPOSITIONS 2- 3- 4-AMINO-3- (2-fluoro-4-phenoxyphenyl) pyrazole 3,4-D pyrimidin-1-yl piperidine-1-carbonyl -4-methyl-4- 4- (OXETAN-3-IL) PIPERAZIN-1-IL PENT-2-ENNITRIL WITH MODIFIED RELEASE

摘要

Modified release formulations, such as solid dosage forms for oral administration, comprising a core composition containing compound (I) and / or a pharmaceutically acceptable salt thereof; a coating sublayer covering a core composition, said coating sublayer comprising polyvinyl alcohol and / or hydroxypropyl methylcellulose; and an enteric coating layer encapsulating the coating sublayer and a core composition, said enteric coating layer comprising at least one polymer selected from a homopolymer of acrylic / methacrylic / ethacrylic acid and copolymers thereof, a cellulose derivative and polyvinylpyrrolidone, and methods for administering a tyrosine B tyrosine inhibitor ) using these formulations.