DIRECT SELECTION OF CELLS EXPRESSING HIGH LEVELS OF HETEROMERIC PROTEINS USING GLUTAMIN SYNTHETIC VECTORS OF INTERNAL COMPLEMENTATION

摘要

This invention relates to the general field of recombinant expression of polypeptides in an animal cell culture. More specifically, the invention relates to improved selection of cells transfected with recombinantly constructed vectors for the expression of polypeptides, in particular heteromultimeric polypeptides.