DENDRIMER-LIKE AMINOAMIDES WITH THE ACTIVITY OF SODIUM CHANNEL BLOCKS FOR THE TREATMENT OF EYE DRY AND OTHER DISEASES OF Mucous membranes

摘要

The present invention provides sodium channel blockers represented by the formula: wherein their structural variables are defined in the description of the invention. The present invention also includes various compositions, combinations and methods of treatment using these sodium channel blockers according to the present invention. An object of the present invention is to provide compounds that are more active and / or not so rapidly absorbed from the surface of the mucous membranes, for example the surface of the eyes, and / or have a less reversible effect compared to known compounds. In particular, it is an object of the present invention to provide methods of treatment based on rehydration of mucosal surfaces.