Drug synthesis with Texas and tramadol

摘要

A pharmaceutical composition in solid oral dosage form, comprising: i) a combination of two pharmacological active ingredients: dexketoprofen salt with an organic or inorganic base and tramadol salt with an organic or inorganic acid, where - the organic or inorganic base is selected from the group: trometamol, trimethylamine, dimethylamine, ethylamine, triethylamine, diethylamine, L-lysine, L-arginine, diethanolamine, sodium hydroxide, calcium hydroxide - organic or inorganic acid is selected from the group: hydrochloric, hydrobromic , phosphoric, sulfuric, methanesulfonic, benzenesulfonic, toluenesulfonic, acetic, propionic, malic,Malico, succinco, cirico, l-tar tar ICO, lactico, malonic, asparctico, glutamic; ii) microcrystalline cellulose as a load; iii) polymers selected from the group: corn starch, corn starch pre coagulation, Hebron or mixtures thereof; IV) drug acceptable effluents.