Drugs intermediates 2,5-dichlorobenzoic acid synthesis method, comprises the following steps: 2 mol 2,5-dichloro-6-aminobenzoic acid, 3-5 mol diisobutyl adipate solution were added to the reaction vessel, the temperature of the solution was raised to 70-78 and the stirring speed was controlled at 130-160 rpm, 3-4 mol cobalt naphthenate was added by 3-5 times, each time the interval was about 30-40 min, continued to react for 90-120 min, added 1200 ml potassium chloride solution, after the solution layered, reduced the solution temperature to 10-15 °C, added oxalic acid solution to adjust the pH to 4-5, washed with potassium sulfate solution, washed with methyl tert-butyl ether solution, and washed with 2-methyl tetrahydrofuran solution, vacuum distillation, collected fractions of 110-120 °C, dehydrated with dehydrating agent, finally obtained 2,5-dichlorobenzoic acid.
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