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Agent for inhibiting binding of a dnabii polypeptide to a microbial dna for prevention of microbial biofilms
Agent for inhibiting binding of a dnabii polypeptide to a microbial dna for prevention of microbial biofilms
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机译:抑制脱纳比多肽与微生物脱氧核糖核酸的结合的剂防止微生物生物膜
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摘要
This invention provides isolated or recombinant polypeptides that are useful to vaccinate individuals suffering from chronic/recurrent biofilm disease or as a therapeutic for those with an existing infection. The individual's immune system will then naturally generate antibodies which prevent or clear these bacteria from the host by interfering with the construction and or maintenance of a functional protective biofilm. Alternatively, antibodies to the polypeptides can be administered to treat or prevent infection. Bacteria that cannot form functional biofilms are more readily cleared by the remainder of the host's immune system.
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