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Lower dosage strength imiquimod formulations and short dosing regimens for treating actinic keratosis
Lower dosage strength imiquimod formulations and short dosing regimens for treating actinic keratosis
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机译:较低剂量强度的咪喹莫特制剂和短剂量方案,用于治疗光化性角化病
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摘要
Pharmaceutical formulations and methods for the topical or transdermal delivery of 1-isobutyl-1H-imidazo[4,5-c]-quinolin-4-amine or 1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine, i.e., imiquimod, to treat actinic keratosis with short durations of therapy, than currently prescribed for the commercially available Aldara® 5% imiquimod cream, as now approved by the U.S. Food & Drug Administration (FDA), are disclosed and described. More specifically, lower dosage strength imiquimod formulations to deliver an efficacious dose of imiquimod for treating actinic keratosis with an acceptable safety profile and dosing regimens that are short and more convenient for patient use than the dosing regimen currently approved by the U.S. Food & Drug Administration (FDA) for Aldara® 5% imiquimod cream to treat actinic keratosis are also disclosed and described.
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