ISOCYTOSINE DEAMINASE/5-FLUOROISOCYTOSINE ENZYME/PRODRUG PAIR FOR GENE-DIRECTED CANCER THERAPY

摘要

This invention is related to a new enzyme/prodrug system for gene-directed enzyme cancer therapy. Newly discovered enzymes - isocytosine deaminases - are able to convert a newly discovered prodrug - 5-fluoroisocytosine - into toxic drug 5-fluorouracil, which can be used for the treatment of various cancers and functional cell research.