acetone solvate of cabazitaxel acetone solvate, or designated acetone solvate of dimethoxy docetaxel or (2r, 3s) - 3 - (2 - hydroxy - 3 tertbutoxycarbonylamino - 4 - acetoxy phu00e9nylpropionate a 5u00df benzoyloxy - 20 - epoxy - 1 - hydroxy - 7u00df - dimethoxy - 9, 10 - oxo - tax 11 - 13 - acetate (acu00e9tonate made the cabazita xel)

摘要

The acetone solvate (A) of 4-acetoxy-2alpha -benzoyloxy-5beta ,20-epoxy-1-hydroxy-7beta ,10beta -dimethoxy-9-oxo-tax-11-en-13alpha -yl (2R,3S)-3-tert. butoxycarbonylamino-2-hydroxy-3-phenylpropionate (I) (i.e. dimethoxy docetaxel) (preferably containing 5-7 wt. % acetone) is new. An independent claim is included for the preparation of (A). ACTIVITY : Cytostatic. MECHANISM OF ACTION : None given in the source material.