INJECTABLE SOLUTION AT PH 7, COMPRISING AT LEAST ONE BASAL INSULIN WHOSE PI IS BETWEEN 5.8 AND 8.5, A PRANDIAL INSULIN AND/OR A GASTROINTESTINAL HORMONE, AND A COPOLYAMINO ACID BEARING CARBOXYLATE CHARGES AND HYDROPHOBIC RADICALS.

摘要

The invention relates to stable compositions physically in the form of an injectable aqueous solution whose pH is between 6.0 and 8.0, comprising at least: a) a basal insulin whose isoelectric point (pI) is between 5.8 and 8.5, b) a prandial insulin or a gastrointestinal hormone, and c) a copolyamino acid bearing carboxylate charges and at least one hydrophobic radical.