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MRNA-BASED GENE EXPRESSION FOR PERSONALIZING PATIENT CANCER THERAPY WITH AN MDM2 ANTAGONIST.
MRNA-BASED GENE EXPRESSION FOR PERSONALIZING PATIENT CANCER THERAPY WITH AN MDM2 ANTAGONIST.
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机译:基于MRNA的基因表达,用于与MDM2拮抗剂进行个性化的癌症治疗。
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摘要
The present application discloses a method to predict responsiveness of a patient, with cancer, to treatment with an MDM2 antagonist of formulae I, II and III as disclosed herein, said method comprising measuring m RNA expression levels of at least MDM2, preferably of a four gene panel comprising MDM2, XPC, BBC3 and CDKN2A, as a biomarker for predicting the response.
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