Analysis of new anthrax to replace single-ring and bicycle ring systems as PRMT5 inhibitors

摘要

1. A formula compound (I) or a salt with acceptable efficacy, wherein R1 and R2 are H-C (= O) (-) (C1-4 tar);This is - ch2-o-cf2Z is -CH2.-C? Page: 1Among other things, AR is a monocyclic aromatic ring, such as pyridine, pyridinediol or bicycle ring system; het is a heterocyclic aromatic bicycle ring system selected from (A-1),(A-2) and (A-3);R3a, R3d and R3e are H, halo, among others; R4a, R4d, R4e, R4f and R4g are H, C1-4 alkyl, among others; Q1 is N or CR6a; Q2 is N or CR6b; Q8 is N or CR6g; Q9 is N or CR6h; Q10 is N or CR6i; Q11 is N or CR6j; R6a, R6b, R6h, R6i and R6j are H, halo, among others; Q5 is N or CR3d, Q6 is N or CR4e; Q7 is N or CR4f. It also refers to pharmaceutical compositions comprising the compound of the invention and methods of preparation. These compounds are inhibitors of the protein arginine methyltransferase 5 (PRMT5) and are useful in the treatment of diseases such as cancer.