Chiral selenourea derivatives containing the group of dehydroabietylamine and alkaloids of cinchona tree and method for producing them

摘要

the subject application is selenomocznikowe chiral derivatives containing group dehydroabietyloaminy and alkaloids of trees of general formula 1,containing in position n group dehydroabietylowu0105 [(1r, 4as, 10ar) - 1,4a-dimethyl-7 - isopropyl - 1,2,3,4,4a, 9,10,10a - oktahydrofenantrenylo - 1 - methyl]while in position n 'containing skeleton alkaloidowy quinine or quinidine, constituting a system.the application also relates to manufacture chiralnych selenomocznikowych derivatives containing group dehydroabietyloaminy and alkaloids of trees, of the general formula 1.who is that in the first stage dehydroabietyloaminu0119 undergo reaction formylowania, and the n - formylodehydroabietyloaminu0119 into izonitryl,which is then subjected to reaction with selenium.then in the final stage of the izoselenonitryl model 2 is subjected to reaction with 9 - amino - (9 - deoksy) derivative of the model 3 in temperature from 273 k to 295 k,in an organic solvent.