Cis-and trans-platinum(II) complex compounds with 3,5-dimethyl-4-introizoksazolem having antitumor activity process for their preparation and separation of

摘要

complexes of platinum (ii) with 3,5 - dimethyl - 4 - nitroizoksazolem of general formula pt (3,5 - dimethyl - 4 - nitroizoksazol) factorial design, where x is the anion of a halogen such as cl -, br - or i - or the rest of karboksylanowu0105 organic acid rcoo -.compounds are characterised by the fact that it is dichlorobis cis - (3,5 - dimethyl - 4 - nitroizoksazol) platinum (ii) of the formula 1 or dichlorobis trans - (3,5 - dimethyl - 4 - nitroizoksazol) platinum (ii) of the formula (2).the invention also includes the method of mixtures of cis - dichlorobis (3,5 - dimethyl - 4 - nitroizoksazol) platinum (ii) and trans - dichlorobis (3,5 - dimethyl - 4 - nitroizoksazol) platinum (ii), which is that tetrachloroplatynian potassium (k2ptcl4) undergo reaction with 3,5 - dimethyl - 4 - nitro izoksazolem in environment water acetonowym,favourably in darkness and the distribution of cis - and trans isomers of platinum (ii) - complex compounds of the formula 1 and 2, which is that a mixture of cis - and trans isomers are separated on chromatographic column - filled with silica gel using as el uent chloroform or chloroform mixture with acetone.in addition, the invention includes the use of compounds of the formula 1 and 2 for the production of anticancer medicine.