notified are derivatives of n-acetyl - s - (n -? - (diarylofosforylo) alkyl tiokarbamoilo) cysteine of the general formula 1 in which r is substituent: 4 - chloro, 3 - chloro, 2 - or 4 - chloro methoxy,while n is 3 or 4 carbon atoms in the alkyl chain.the application also includes a method of their manufacture, which is that n - acetyl - l - cysteine (nac) and sodium bicarbonate dissolved in watersubsequently, this solution wkrapla is dissolved in ethyl alcohol bis - arylowy ester? - izotiocyjanianoalkilofosfonowy,after the solvent vaporized under a reduced pressure and is extracted using hexane and aqueous layer are acidified with hydrochloric acid, ethyl acetate is extracted and drought on anhydrous magnesium sulphateand then the solvent vaporized under reduced pressure with the target products.the application also relates to the application of derivative n - acetyl - s - (n -? - (diarylofosforylo) alkyl tiokarbamoilo) cysteine of the general formula 1 in which r is substituent: 4 - chloro, 3 - chloro.2 - chloro or 4 - methoxy and n is 3 or 4 carbon atoms in the alkyl chain as antibacterial agents.in particular, to eliminate bacteria such as gram positive staphylococcus aureus.
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