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Formulation of nanostructured lipid carriers and method for producing it

机译:纳米结构脂质载体的配制及其制备方法

摘要

the subject invention is nanostructured lipid carriers formulation which contains: - from 1 wt%. to 5 wt%. seed oil obtained by extraction of black currant seeds nadkrytycznym co2; - 5 wt%. to 15 wt%. modified beeswax; - 2 wt%. to 5 wt%.a nonionic emulsifier with hydrophilic group alkilopoliglukozydu00f3w; - deionised water in addition to 100 wt%.formulacju0119 nanostructured lipid carriers produces way, which includes the following steps: (a) heating the oil phase containing oil with blackcurrant seeds - liquid lipid and modified beeswax - solid lipid, to temperature 5u00b0c - 50 degrees above the tempera tours of standing lipidu; (b) heating the aqueous phase.it is a mixture of emulsifier and water temperature 5u00b0c - 50 degrees above the melting temperature of lipidu; c) putting oil phase to aqueous phase and zdyspergowanie mixture; (d)... mix obtained in section (c) pre emulsion; (e) the gradual cooling obtained formulation to tempera round of peace.favourably... mix obtained in point c) pre emulsion is ultrasonifikacji method.
机译:本发明是纳米结构的脂质载体制剂,其包含:-1重量%。至5重量%。通过提取黑加仑子种子nadkrytycznym co2获得的种子油; -5重量%。至15重量%。改性蜂蜡-2重量%。至5重量%。具有亲水基alkilopoliglukozyd的非离子型乳化剂。 -除100 wt%的去离子水外,还产生了纳米结构脂质载体的方法,该方法包括以下步骤:(a)将含有油和黑加仑子种子的油相加热-液体脂质和改性蜂蜡-固体脂质,加热至温度5 u00b0c-站立下的脂质体的气膜行程高于50度; (b)加热水相。它是乳化剂和水的混合物,水的温度比脂质的熔融温度高5-50℃。 c)将油相置于水相和zdyspergowanie混合物中; (d)...在(c)节中获得的预乳液混合物; (e)将得到的逐渐冷却的配方调和为平和。有利地,在c)点中获得的混合物是超音波法。

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