INDOLE AND CARBAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MRSA SENSITIVE ANTIBIOTICS

摘要

The 1,3-bis(indol-3-yl)-tetrahydrocyclopenta[b]indoles, 1,4-bis(indol-3-yl)tetrahydrocarbazoles, 6,10-bis(indol-3-yl)hexahydrocyclohepta[b]indoles, 6,11-bis(indol-3-yl)hexahydrocycloocta[b]indoles and 11-(indol-3-yl)benzo[b]carbazoles of the general formulae and developed in accordance with the invention have a selective inhibiting effect on the growth of S. aureus and the methicillin-resistant S. aureus (MRSA) in the lower micro-molecular concentration range in a screening of additional Gram-positive and Gram-negative bacteria and fungi. The production of the compounds from dialdehydes and indoles at room temperature in glacial acetic acid constitutes a protective method in which the new structures are available with very good yields in some cases.