ANTISENSE-OLIGONUCLEOTIDES AS INHIBITORS OF TGF-R SIGNALING

摘要

The present invention relates to antisense-oligonucleotides having a length of at least 8 nucleotides, wherein at least two of the nucleotides are LNAs, their use as inhibitors of TGF-R signaling, pharmaceutical compositions containing such antisense-oligonucleotides and the use for prophylaxis and treatment of neurological, neurodegenerative and hyperproliferative diseases.