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Delivery system for sustained release of a calcium-channel blocking agent
Delivery system for sustained release of a calcium-channel blocking agent
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机译:缓释钙通道阻滞剂的释放系统
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摘要
A delivery system for sustained release of a calcium-channel blocking agent is adapted for introduction in the cerebrospinal fluid of a subject. The delivery system comprises a solid dispersion product of a calcium-channel blocking agent in a mixture of a (i) first poly(lactide-co-glycolide) having a molecular weight distribution centered around a first number average molecular weight Mn1 and a (ii) second poly(lactide-co-glycolide) having a molecular weight distribution centered around a second number average molecular weight Mn2, wherein Mn1 is in the range of from 2000 to 3000 g/mol and the ratio of Mn1/Mn2 is from 1.8 to 3.5. The delivery system is deposited in the vicinity of or adjacent to a blood vessel showing vasospasm or suspected of developing vasospasm.
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机译:用于持续释放钙通道阻断剂的递送系统适于引入受试者的脑脊髓液中。递送系统包括钙通道阻断剂在(i)分子量分布以第一数均分子量Mn1为中心的第一聚(丙交酯-共-乙交酯)的固体分散产物和(ii)的混合物中的固体分散产物。 )具有以第二数均分子量Mn2为中心的分子量分布的第二聚(丙交酯-共-乙交酯),其中Mn1在2000至3000 g / mol的范围内,Mn1 / Mn2的比为1.8至3.5。递送系统沉积在显示血管痉挛或怀疑正在发展的血管痉挛的血管附近或附近。
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