首页> 外国专利> A PROCESS FOR THE PREPARATION OF CGMP-PHOSPHODIESTERASE INHIBITOR AND ORAL PHARMACEUTICAL FORMULATION COMPRISING TADALAFIL CO-PRECIPITATES

A PROCESS FOR THE PREPARATION OF CGMP-PHOSPHODIESTERASE INHIBITOR AND ORAL PHARMACEUTICAL FORMULATION COMPRISING TADALAFIL CO-PRECIPITATES

机译:包含他达拉非共沉淀的CGMP-磷酸酯酶抑制剂和口服药物制剂的制备方法

摘要

The present invention relates to an improved process for preparation of tadalafil and crystallization and/or purification thereof, wherein the processes are conducted at increased pressure. The invention relates also to a process for preparation of tadalafil co-precipitates and to a solid pharmaceutical composition comprising tadalafil co-precipitates and at least one water soluble diluent and/or water insoluble non-swellable diluent, wherein the composition is substantially free of water insoluble swellable diluents.
机译:本发明涉及他达拉非的制备及其结晶和/或纯化的改进方法,其中该方法在升高的压力下进行。本发明还涉及他达拉非共沉淀物的制备方法,以及包含他达拉非共沉淀物和至少一种水溶性稀释剂和/或水不溶性非溶胀性稀释剂的固体药物组合物,其中该组合物基本上不含水。不溶性可溶胀稀释剂。

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