ANTIGEN DISCOVERY FOR T CELL RECEPTORS ISOLATED FROM PATIENT TUMORS RECOGNIZING WILD-TYPE ANTIGENS AND POTENT PEPTIDE MIMOTOPES

摘要

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 27 September 2018 (27.09.2018) o n °nolo VIII (10) International Publication Number WO 2018/175585 A3 WIPO I PCT (51) International Patent Classification: C12Q 1/68 (2018.01) C12N 15/09 (2006.01) (21) International Application Number: PCT/US2018/023569 (22) International Filing Date: 21 March 2018 (21.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/476,575 24 March 2017 (24.03.2017) US (71) Applicant: THE BOARD OF TRUSTEES OF THE LE- LAND STANFORD JUNIOR UNIVERSITY [US/US]; Office of the General Counsel, Building 170, 3rd Floor, Main Quad P.O. Box 20386, Stanford, California 94305-2038 (US). (72) Inventors: GEE, Marvin; 2100 Geng Road, Suite 200, Palo Alto, California 94303 (US). DAVIS, Mark M.; 52 Euclid Avenue, Atherton, California 94027 (US). HAN, Arnold; 81 Walworth Avenue, Scarsdale, New York 10583 (US). GARCIA, Kenan Christopher; 580 Kenwood Dri- ve, Menlo Park, California 94025 (US). = (74) Agent: SHERWOOD, Pamela J.; Bozicevic, Field & Francis LLP, 201 Redwood Shores Parkway, Suite 200, Redwood City, California 94065 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). W O 20 18/ 1755 85 A3 Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a)) (88) Date of publication of the international search report: 01 November 2018 (01.11.2018) (54) Title: ANTIGEN DISCOVERY FORT CELL RECEPTORS ISOLATED FROM PATIENT TUMORS RECOGNIZING WILD- TYPE ANTIGENS AND POTENT PEPTIDE MIMOTOPES (57) : Compositions and methods are provided for peptide sequences that are ligands for a T cell receptor (TCR) of interest, in a given MHC context.