A stable pharmaceutical composition containing amlodipine and valsartan

摘要

A method of producing a monolayer tablet containing amlodipine and valsartan or its pharmaceutically acceptable salts, characterized in that a) valsartan granules or their pharmaceutically acceptable salt, together with at least one pharmaceutically acceptable excipient, is used with the use of water as a wetting agent , b) amlodipine or its pharmaceutically acceptable salt is granulated by dry route, together with at least one pharmaceutically acceptable excipient, c) the granules obtained from amlodipine are mixed with the granules of valsartan and with at least one pharmaceutically acceptable excipient, the mixing and compressing the tabletting mixture to obtain solid pieces - the cores - and d) is optionally provided to the cores obtained from a coating.