Resolvins: biological models for therapeutic interventions

摘要

Compound having a structure of the formula: ** Formula ** in which P1 and P2 each individually is a hydrogen atom or a hydroxyl protecting group selected from an acyl group, an alkyl group, a tetrahydropyranyl group, a trialkylsilyl group, a glycol group and an allyl group; Z is -C (O) ORd, -C (O) NRcRc, -C (O) H, -C (NH) NRcRc, -C (S) H, -C (S) ORd, -C (S) NRcRc or -CN; each Ra is independently selected from hydrogen, (C1-C6) alkyl, cycloalkyl (C3-C8), cyclohexyl, cycloalkylalkyl (C4-C11), aryl (C5-C10), phenyl, arylalkyl (C6-C16), benzyl, 2 to 6 membered heteroalkyl, 3 to 8 membered cycloheteroalkyl, morpholinyl, piperazinyl, homopiperazinyl, piperidinyl, cycloheteroalkylalkyl of 4 to 11 members, heteroaryl of 5 to 10 members and heteroarylalkyl of 6 to 16 members; each Rb is a suitable group independently selected from = O, -ORd, haloalkyloxy (C1-C3), -OCF3, = S, -SRd, = NRd, = NORd, -NRcRc, halogen, -CF3, -CN, - NC, -OCN, -SCN, -NO, -NO2, = N2, -N3, -S (O) Rd, -S (O) 2Rd, -S (O) 2ORd, -S (O) NRcRc, -S (O) 2NRcRc, -OS (O) Rd, -OS (O) 2Rd, -OS (O) 2ORd, -OS (O) 2NRcRc, -C (O) Rd, -C (O) ORd, -C ( O) NRcRc, -C (NH) NRcRc, -C (NRa) NRcRc, -C (NOH) Ra, -C (NOH) NRcRc, -OC (O) Rd, -OC (O) Rd, -OC (O ) NRcRc, -OC (NH) NRcRc, -OC (NRa) NRcRc, - [NHC (O)] nRd, - [NRaC (O)] nRd, - [NHC (O)] nORd, - [NRaC (O) ] nORd, - [NRaC (O)] nNRcRc, - [NRaC (O)] nNRcRc, - [NHC (NH)] nNRcRc and - [NRaC (NRa)] nNRcRc; each Rc is independently a protective group or Ra, or, alternatively, each Rc is taken together with the nitrogen atom to which it is attached to form a 5- to 8-membered cycloheteroalkyl or heteroaryl which may optionally include one or more of the heteroatoms same or different additional ones and which may optionally be substituted with one or more of the same or different Ra groups or suitable Rb; each Rd is independently a protective group or Ra; and each n is independently an integer from 0 to 3, in which any carbon-carbon double bond can be cis or trans, or a pharmaceutically acceptable salt thereof, in which the protective group represented by Rc and Rd is independently selected. from allyl 2-trimethylsilyl-ethanesulfonyl formyl, acetyl, trifluoroacetyl, benzyl, benzyloxycarbonyl, tert-butoxycarbonyl, trimethylsilyl, trityl and substituted trityl groups, allyloxycarbonyl, 9- fluorenylmethyloxycarbonyl, nitro-veratryloxycarbonyl, tetrahydropyranyl, and glycol.