A prolonged release pharmaceutical composition comprising (A) hydromorphone hydrochloride or oxycodone hydrochloride hydrate, (B) hydroxypropylmethylcellulose acetate succinate having a median statistic (D50) of 40 µm or less, (C) hydroxypropylcellulose and ( D) a saccharide, in which the content ratio of component (C) to component (B) by weight in the composition, (C) / (B), is 10/4 to 7/7.
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