PROCEDURE FOR PREPARING ACID METHYL ESTERTER 3 - (4S) -8-BROMO-1-METHYL-6- (PYRIDIN-2-IL) -4H-IMIDAZO 1,2-A 1,4 BENZODIAZEPIN-4 -IL -PROPIONIC, AND USEFUL COMPOUNDS IN THAT PROCEDURE (Machine-translation by Google Translate, not legally binding)

摘要

Procedure for preparing 3 - [(4S) -8-bromo-1-methyl-6- (pyridin-2-yl) -4H-imidazo [1,2-a] [1,4] benzodiazepin-4-methyl ester -yl] -propionic, and compounds useful in that procedure. The present invention relates to a process for preparing methyl ester of 3 - [(4S) -8-bromo-1-methyl-6- (pyridin-2-yl) -4H-imidazo [1,2-a] [ 1,4] benzodiazepin-4-yl] -propionic acid, starting from the methyl ester of 3 - [(3S) -7-bromo-2-oxo-5- (pyridin-2-yl) -2,3-dihydro- 1H- [1,4] -benzodiazepin-3-yl] propionic, and new compounds useful as intermediates in that process, the methyl ester of (3S) -3- [7-bromo-2- (2,2-dimethoxypropylamino) -5-pyridin-2-yl-3H-benzo [e] [1,4] diazepin-3-yl] propionic acid. (Machine-translation by Google Translate, not legally binding)