Method to evaluate the activity of an auto-inflammatory disease

摘要

An ex vivo method implemented by computer to determine the activity of an auto-inflammatory disease in a patient, in which said auto-inflammatory disease is selected from the group consisting of a hereditary recurrent fever syndrome (sFRH), mevalonate kinase deficiency (MKD) , periodic syndrome associated with the tumor necrosis factor (TNF) receptor (TRAPS), and periodic cryopyrine-associated syndromes (CAPS), which includes the stages of: a) Having, in said patient's daily statement, for a monthly period, the state of 12 aspects that consist of, Fever = 38 ° C, General symptoms, Abdominal pain, Nausea / vomiting, Diarrhea, Headache, Chest pain, Node pain, Arthralgia or myalgia, Joint inflammation, Ocular manifestations, Skin rash , b) Retrieve said communications from said patient c) Assign the value "1" to each aspect that said patient noted as present and assign the value "0" to each aspect that e The patient noted as absent d) Combine, by means of an algebraic sum, all the values obtained in stage c) during each of the days of a period of one consecutive month, to obtain a final value, in which said auto-inflammatory disease is active in said patient if said final value is higher than a predetermined limit, in which said predetermined limit has a value of 9.