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Nanoparticle-mediated gene delivery, genomic editing and modification that target ligands in various cell populations
Nanoparticle-mediated gene delivery, genomic editing and modification that target ligands in various cell populations
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机译:纳米粒子介导的基因传递,基因组编辑和修饰,可靶向各种细胞群体中的配体
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摘要
An improved nanoparticle for transfecting cells is provided. The nanoparticle includes a core polyplex and a silica coating on the core polyplex and, optionally, a polymer attached to an outer surface of the silica coating , where the polyplex includes an anionic polymer, a cationic polymer, a cationic polypeptide, and a polynucleotide. Also provided is an improved method of modifying intracellular polynucleotides. The method includes contacting a cell with a nanoparticle that includes a core polyplex and a silica coating on the core polyplex and, optionally, a polymer attached to an outer surface of the silica coating, where the polyplex includes an anionic polymer, a cationic polymer, a cationic polypeptide, and a polynucleotide.
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