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Aqueous powder and extended-release suspension comprising methylphenidate
Aqueous powder and extended-release suspension comprising methylphenidate
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机译:包含哌醋甲酯的水性粉末和缓释悬浮液
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摘要
An oral methylphenidate powder which is reconstitutable into a final oral aqueous sustained release formulation containing at least about 50% or at least about 80% by weight water based on the total weight of the suspension, is provided. The powder is a blend containing a combination of an uncoated methylphenidate - ion exchange resin complex, a barrier coated methylphenidate - ion exchange resin complex - matrix, and a water soluble buffering agent such that upon formed into an aqueous liquid formulation, the formulation has a pH in the range of about 3.5 to about 5, or about 4 Lo about 4.5. Following administration of a single dose of the oral aqueous methylphenidate suspension, a therapeutically effective amount of methylphenidate is reached in less than one hour and the composition provides a twelve-hour extended release profile.
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