INHIBITION OF INTRACELLULAR GROWTH OF MYCOBACTERIUM SPECIES AND ITS APPLICATIONS

摘要

Disclosed is a method of preventing, treating or inhibiting intracellular mycobacterial infection in a patient in need thereo comprising administering a compound which activates activity of an NAD+-dependent deacetylase such as sirtuins 1, 2, 3, 4, 5, 6 and 7. In one preferred embodiment, the agent activates NAD-dependent deacetylase SIRT1, and may be SRT1720. Also disclosed is the use of sirtuin enhancers in combination with other anti-tuberculosis drugs for treatment of mycobacterial infection, in particular, the use of SRT1720 and isoniazid (INH).