SINGLE NUCLEOTIDE POLYMORPHIC MARKER COMPOSITION FOR PREDICTING RESPONSE TO ANTI-TNF PREPARATION, AND METHOD USING SAME TO PREDICT RESPONSE TO ANTI-TNF PREPARATION

摘要

The present invention relates to a single nucleotide polymorphic marker composition for predicting response to an anti-TNF preparation, and a method using same to predict response to an anti-TNF preparation. With respect to IFX, the inventors classified a total of 349 CD registered patients into a good responder group containing 42 patients, a non-responder group containing 70 patients, and an intermediate responder group containing 237 patients, and analyzed a total of 112 patients through linkage analysis. 58 patients (15 in the good responder group and 43 in the non-responder group) were analyzed in a discovery analysis, and 54 patients (27 in the good responder group and 27 in the non-responder group) were analyzed in a replication analysis. As a result of the analyses, an rs2158962 SNP variation relating to better response to IFX treatment was identified, and a high frequency of the "A" allele was found in the good responder groups. Accordingly, the present invention can be usefully applied to establishing a treatment strategy and carrying out patient-tailored treatment during the IFX treatment of CD patients.