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OLIGONUCLEOTIDE PROBE ARRAY WITH ELECTRONIC DETECTION SYSTEM
OLIGONUCLEOTIDE PROBE ARRAY WITH ELECTRONIC DETECTION SYSTEM
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机译:带电子检测系统的寡核苷酸探针阵列
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摘要
The present disclosure provides methods, device, and system for a hybridization assay to detect nucleic acid targets. The assay may use a probe array format with addressable microwells. Each microwell may retain a plurality of copies of one probe which may be complementary to a portion of a specific nucleic acid target. The plurality of copies of probes may be produced from a pooled library of probe sequences by amplification techniques, including, rolling circle amplification and emulsion-PCR. Detection of hybridization may rely on methods using ion-sensitive field effect transistor (ISFET) and optical detectors to detect signals indicating the presence of the nucleic acid targets.
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