TRANSDERMAL CREAM FOR TREATING DUPUYTREN'S CONTRACTURE

摘要

A pharmaceutically acceptable transdermal composition for the treatment of patients with musculoskeletal connective tissue fibrosis or a disorder including Dupuytren's Contracture, Peyronie's disease, Ledderhose disease, or Knuckle Pads, includes an active composition and a base composition. The active composition is present in the transdermal composition in an amount of about 10% to about 40% by weight of the transdermal composition and includes one or more growth factor antagonists. The base composition is present in an amount of about 60% to about 90%) by weight of the transdermal composition and comprises a transdermal delivery system or transdermal carrier. A method of treating patients with musculoskeletal connective tissue fibrosis, including topically applying the transdermal composition in effective amount to the affected tissue is further disclosed.