A branched polyglycol epoxy derivative cross-linked sodium hyaluronate gel, preparation therefor, and an application thereof. A cross-linking agent used in the prepared cross-linked sodium hyaluronate gel is a polyglycol epoxy derivative. There is a plurality of ether bonds present in the molecules of the polyglycol epoxy derivative, such that more hydrogen bonds are present in the gel system, thereby enhancing the stability of the gel. Moreover, due to the special spatial structure of the branched polyglycol derivative, the winding spatial structure of the prepared gel is more complex, such that the prepared gel is more stable. Because the related branched polyglycol epoxy derivative is a single molecular weight compound, the prepared gel product has good batch stability.
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