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HYDROXYLAPATITE/GELATINE COMPOSITE MATERIAL AND THE USE OF SAME, PARTICULARLY AS ARTIFICIAL IVORY, AND METHOD FOR PRODUCING SAME

机译:羟基磷灰石/明胶复合材料及其用途,特别是作为人造象牙的用途及其制备方法

摘要

The invention relates to a method for producing a multi-purpose isotropic hydroxylapatite/gelatine composite material, involving at least the following steps: a) providing a suspension of powdered hydroxylapatite in a liquid medium selected from the group comprising a C1-C10 alcohol, particularly ethanol, another dispersing agent that can be mixed with water, water, and mixtures thereof; b) adding an aqueous solution of gelatine, preferably at a concentration of 5 to 25 wt.% gelatine, to the suspension; c) agitating the mixture at a predefined temperature for a predefined period of time, preferably in the region of 1 to 10 hours, until the liquid medium has been fully or partially evaporated; and d) optionally drying the product obtained in step c). In a specific embodiment, the method is characterised in that the product obtained in step c) or d) is additionally infiltrated with at least one aliphatic polyether in an additional step e1). In another specific embodiment, the method is characterised in that the product obtained in step c), d) or e1) is additionally brought into contact with at least one agent for crosslinking the gelatine chains, in step e2). A further aspect of the invention relates to the composite material produced using the method described above, and the use of same, particularly as artificial ivory.
机译:本发明涉及一种用于生产多用途各向同性羟基磷灰石/明胶复合材料的方法,该方法至少包括以下步骤:a)提供粉末状羟基磷灰石在选自C 1 -C 10醇的液体介质中的悬浮液,特别是乙醇,可以与水,水及其混合物混合的另一种分散剂; b)向该悬浮液中加入明胶的水溶液,优选浓度为5至25重量%的明胶。 c)在预定温度下将混合物搅拌预定的时间,优选在1至10小时的范围内,直到液体介质完全或部分蒸发为止; d)任选地干燥步骤c)中获得的产物。在一个具体的实施方案中,该方法的特征在于,在另外的步骤e1)中用至少一种脂族聚醚另外渗透在步骤c)或d)中获得的产物。在另一个具体的实施方案中,该方法的特征在于,在步骤e2)中,使步骤c),d)或e1)中获得的产物另外与至少一种用于交联明胶链的试剂接触。本发明的另一方面涉及使用上述方法生产的复合材料及其用途,尤其是作为人造象牙。

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