METHODS FOR ISOLATING AND ENRICHING POPULATIONS OF BIOFLUID- DERIVED EXTRACELLULAR VESICLES, AND METHODS OF USE THEREOF

摘要

The invention relates generally to a process for isolating subpopulations of EVs to identify biomarkers useful identifying, determining the progression of, and/or prognosing a disease, including a neurological disease. More particularly, the present invention relates to detection technology of various exosomal biomarkers including proteins, protein modifications, sugars, RNA, DNA, lipids, and metabolites, and combinations thereof.