CHITINASE-3-LIKE PROTEIN 1 (CHI3L1) AS AN AUTOANTIGEN IN AUTOIMMUNE DISORDERS OF THE DIGESTIVE SYSTEM

摘要

The invention relates to an in vitro method for diagnosis, prognosis, risk assessment, monitoring, therapy guidance and/or therapy control of an autoimmune disorder of the digestive system, such as inflammatory bowel disease and autoimmune liver disease, in which autoantibodies that bind Chitinase-3-Like Protein 1 (CHI3L1) protein are detected as a marker of such disease. The invention therefore relate to the use of CHI3L1 as an autoantigen in autoimmune diagnostics if diseases of the digestive system. A kit and system for conducting the method are encompassed by the invention.