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ENGINEERED VARIANTS OF HIV-1 ENV FOR PRESENTATION OF QUARTERNARY EPITOPES
ENGINEERED VARIANTS OF HIV-1 ENV FOR PRESENTATION OF QUARTERNARY EPITOPES
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机译:用于表皮表达的HIV-1 ENV工程变种
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摘要
Provided herein are HIV-1 Env proteins or fragments thereof comprising one or more amino acid mutations; and nucleic acid molecule encoding the same. Further provided is a method of screening a compound for binding to one or more mutant HIV-1 Env proteins; and methods for eliciting an immune response against an HIV-1 infected cell, comprising administering to a subject an amount of a mutant HIV-1 Env protein, a fragment thereof, a mutant HIV-1 Env trimeric complex, or portion thereof, effective to elicit an immune response in the subject. Further provided is a pharmaceutical composition, such as a vaccine, comprising the mutant HIV-1 Env protein or fragment thereof.
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